Santonox → 2-(5-Phenyl-1-hydroxypentyl)-2-oxiranecarboxylic acid methyl ester

HRID 2232620

反応式

HRID 2232620 の反応式
[CH3:1][O:2][C:3](=[O:18])[C:4](=[CH2:17])[CH:5]([OH:16])[CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.S(C1C(C)=CC(O)=C(C(C)(C)C)C=1)C1C(C)=CC([OH:30])=C(C(C)(C)C)C=1.ClC1C=C(C=CC=1)C(OO)=O>ClCCCl>[CH3:1][O:2][C:3]([C:4]1([CH:5]([OH:16])[CH2:6][CH2:7][CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:17][O:30]1)=[O:18]

参加物

5

反応物 3

HCID 7308SantonoxHCID 70297m-Chloroperbenzoic acidHCID 14348901beta-Hydroxy-alpha-methylenebenzeneheptanoic acid methyl ester

生成物 1

HCID 143489022-(5-Phenyl-1-hydroxypentyl)-2-oxiranecarboxylic acid methyl ester

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

A solution of 11.2 g (45 mmol) of β-hydroxy-α-methylenebenzeneheptanoic acid methyl ester in 300 ml of 1,2-dichloroethane is treated with 200 mg of 4,4'-thiobis(6-t-butyl-m-cresol) and 24.5 g (138 mmol) of m-chloroperoxybenzoic acid. The mixture is heated to reflux under nitrogen for 26 hours.

後処理

  1. temperatureThe mixture is heated
  2. temperatureto reflux under nitrogen for 26 hours

出典と根拠

ORDレコード
ord-2dd5530f6dde4afbad48bab534e5a5a3
出典データセット
uspto-grants-1988_11
特許番号
US04788304

関連ノート

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