Ethanolamine → HCID 68678087、化合物

HRID 2233019ノート

反応式

HRID 2233019 の反応式
[C:1]([C:5]1[N:6]=[C:7](Cl)[C:8]2[N:9]([C:11](=[O:14])[NH:12][N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:16]([CH2:18][NH2:19])[OH:17]>C1COCC1>[C:1]([C:5]1[N:6]=[C:7]([NH:19][CH2:18][CH2:16][OH:17])[C:8]2[N:9]([C:11](=[O:14])[NH:12][N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 700EthanolamineHCID 68676527HCID 68676527、化合物

生成物 1

HCID 68678087HCID 68678087、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 0.50 g of the product of Step F and 0.40 g of ethanolamine in THF (6 mL) was heated at reflux for 16 h. After cooling the reaction mixture to ambient temperature, solvents were removed and the residue was purified by silica gel chromatography to yield the title compound as a white solid. MS (M+H+)=252.3.

後処理

  1. temperatureat reflux for 16 h
  2. customsolvents were removed
  3. customthe residue was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-543f1bd9aebb4f73add199eacbf683b5
出典データセット
uspto-grants-2010_05
特許番号
US07709473B2

反応ノート

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