Methylamine → 1-(Methylamino)cyclopentane-1-carbonitrile

反応式

[CH3:1][NH2:2].[C:3]1(=O)[CH2:7][CH2:6][CH2:5][CH2:4]1.C[Si]([C:13]#[N:14])(C)C>>[CH3:1][NH:2][C:3]1([C:13]#[N:14])[CH2:7][CH2:6][CH2:5][CH2:4]1

参加物

反応物 3

HCID 6329Methylamine

HCID 8452Cyclopentanone

HCID 82115Trimethylsilyl cyanide

生成物 1

HCID 129454451-(Methylamino)cyclopentane-1-carbonitrile

実験手順

Methylamine was bubbled into a refrigerated mixture of cyclopentanone (0.252 g, 3 mmol) and trimethylsilyl cyanide (0.396 g, 4 mmol) until the volume doubled. The mixture was stirred 3 h and then concentrated to dryness to obtain 31a (0.372 g, quantitative).