Hydrochloric Acid → 3-(4-Chlorophenoxy)-5-fluoro-2-methyl-1H-indole-1-acetic acid

HRID 2233737ノート

反応式

HRID 2233737 の反応式
[OH-].[Na+].[Cl:3][C:4]1[CH:27]=[CH:26][C:7]([O:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([F:18])[CH:16]=3)[N:11]([CH2:19][C:20]([O:22]CC)=[O:21])[C:10]=2[CH3:25])=[CH:6][CH:5]=1.O.Cl>C1COCC1>[Cl:3][C:4]1[CH:27]=[CH:26][C:7]([O:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([F:18])[CH:16]=3)[N:11]([CH2:19][C:20]([OH:22])=[O:21])[C:10]=2[CH3:25])=[CH:6][CH:5]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 116391123-(4-Chlorophenoxy)-5-fluoro-2-methyl-1H-indole-1-acetic acid, ethyl ester

生成物 1

HCID 116885733-(4-Chlorophenoxy)-5-fluoro-2-methyl-1H-indole-1-acetic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 2M sodium hydroxide (3 ml) was added to a stirred mixture of the product from step (ii) (0.36 g), water (10 ml) and THF (10 ml). After 2 h the solution was acidified with 2M hydrochloric acid and extracted with diethylether. The organics were washed with water, dried and evaporated under reduced pressure. The residue was recrystallised from diethylether/isohexane. Yield 138 mg

後処理

  1. extractionextracted with diethylether
  2. washThe organics were washed with water
  3. customdried
  4. customevaporated under reduced pressure
  5. customThe residue was recrystallised from diethylether/isohexane

出典と根拠

ORDレコード
ord-c636743e688149c7b8e3cbf368770efb
出典データセット
uspto-grants-2010_05
特許番号
US07709521B2

反応ノート

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