1-(4-Chlorophenoxy)acetone → HCID 68617744、化合物

HRID 2233741

反応式

HRID 2233741 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11]N.[Cl:13][C:14]1[CH:24]=[CH:23][C:17]([O:18][CH2:19][C:20](=O)[CH3:21])=[CH:16][CH:15]=1>CC#N.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]2[C:3]=1[NH:11][C:20]([CH3:21])=[C:19]2[O:18][C:17]1[CH:16]=[CH:15][C:14]([Cl:13])=[CH:24][CH:23]=1

参加物

5

反応物 2

HCID 2398741-(4-Chlorophenoxy)acetoneHCID 53402499(2-Bromo-5-nitrophenyl)hydrazine

生成物 1

HCID 68617744HCID 68617744、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6342Acetonitrile溶媒

反応条件

温度
75 °C

実験手順

A mixture of the compound from (i) (2.4 g) and 1-(4-Chloro-phenoxy)-propan-2-one (1.65 g) in MeCN (20 ml) and water (5 ml) was stirred for 16 h. The volatiles were removed in vacuo. AcOH (50 ml) was added and the reaction heated at 75° C. for 72 h. The volatiles were evaporated under reduced pressure and the residue was purified by chromatography on silica eluting with 5% ethylacetate/iso-hexane. Yield 0.34 g

後処理

  1. customThe volatiles were removed in vacuo
  2. additionAcOH (50 ml) was added
  3. customThe volatiles were evaporated under reduced pressure
  4. customthe residue was purified by chromatography on silica eluting with 5% ethylacetate/iso-hexane

出典と根拠

ORDレコード
ord-bd892b9f6f3440b48b6590ad1fbadcc5
出典データセット
uspto-grants-2010_05
特許番号
US07709521B2

関連ノート

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