Water → 3-(4-Chlorophenoxy)-2-methyl-5-(methylsulfonyl)-1H-indole-1-acetic acid

HRID 2233750

反応式

HRID 2233750 の反応式
[OH-].[Na+].[Cl:3][C:4]1[CH:29]=[CH:28][C:7]([O:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([S:18]([CH3:21])(=[O:20])=[O:19])[CH:16]=3)[N:11]([CH2:22][C:23]([O:25]C)=[O:24])[C:10]=2[CH3:27])=[CH:6][CH:5]=1.O>C1COCC1>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([S:18]([CH3:21])(=[O:19])=[O:20])[CH:16]=3)[N:11]([CH2:22][C:23]([OH:25])=[O:24])[C:10]=2[CH3:27])=[CH:28][CH:29]=1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 866092343-(4-chlorophenoxy)-2-methyl-5-(methylsulfonyl)-1H-indole-1-acetic acid, methyl ester

生成物 1

HCID 116611643-(4-Chlorophenoxy)-2-methyl-5-(methylsulfonyl)-1H-indole-1-acetic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 1M sodium hydroxide (1 ml) was added to a stirred mixture of the product from step (iii) (235 mg) in THF (1 ml). After 2 h, water (10 ml) was added and the solution extracted with DCM. The solution was acidified with 2 M hydrochloric acid and extracted with ethylacetate. These later organics were dried and evaporated under reduced pressure. Yield 135 mg

後処理

  1. extractionthe solution extracted with DCM
  2. extractionextracted with ethylacetate
  3. customThese later organics were dried
  4. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-b6ce475f2d294a08863291c49d496b3c
出典データセット
uspto-grants-2010_05
特許番号
US07709521B2

関連ノート

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