Ethanol → 3-[(2-Methoxyethyl)amino]-N-methylpropanamide

HRID 2234409

反応式

HRID 2234409 の反応式
[CH3:1][NH:2][C:3](=[O:6])[CH:4]=[CH2:5].[CH3:7][O:8][CH2:9][CH2:10][NH2:11].CCO>CO>[CH3:7][O:8][CH2:9][CH2:10][NH:11][CH2:5][CH2:4][C:3]([NH:2][CH3:1])=[O:6]

参加物

5

反応物 3

HCID 702EthanolHCID 80182-MethoxyethylamineHCID 14471Methylacrylamide

生成物 1

HCID 283071863-[(2-Methoxyethyl)amino]-N-methylpropanamide収率 65%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
140 °C

実験手順

N-Methylacrylamide (ABCR; 500 mg, 5.87 mmol), 2-Methoxyethylamine (Aldrich; 441 mg, 5.87 mmol), and EtOH (2 mL) were combined and heated in a microwave at 140° C. for 40 minutes. The reaction mixture was cooled and added to a 5 g SCX-2 column pre-wet with MeOH (2 column volumes), flushed with MeOH (2 column volumes) then the product eluted with 2M ammonia in MeOH. Product containing fractions were evaporated in vacuo to give the title compound as a clear oil (608 mg, 65%)

後処理

  1. temperatureThe reaction mixture was cooled
  2. customflushed with MeOH (2 column volumes)
  3. washthe product eluted with 2M ammonia in MeOH
  4. additionProduct containing fractions
  5. customwere evaporated in vacuo

出典と根拠

ORDレコード
ord-542e4945d87a4bf388dd5870b467d054
出典データセット
uspto-grants-2010_05
特許番号
US07709471B2

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