Lithium Hydroxide → 5-[cis-3,5-Dimethyl-1-piperazinyl]-3-pyridinecarboxylic acid

HRID 2234991ノート

反応式

HRID 2234991 の反応式
[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:8])[CH2:5][N:4]([C:9]2[CH:10]=[C:11]([C:15]([O:17]CC)=[O:16])[CH:12]=[N:13][CH:14]=2)[CH2:3]1.[OH-].[Li+]>O1CCCC1>[CH3:8][C@H:6]1[NH:7][C@@H:2]([CH3:1])[CH2:3][N:4]([C:9]2[CH:10]=[C:11]([C:15]([OH:17])=[O:16])[CH:12]=[N:13][CH:14]=2)[CH2:5]1

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 58988147Ethyl 5-[cis-3,5-dimethyl-1-piperazinyl]-3-pyridinecarboxylate

生成物 1

HCID 589881255-[cis-3,5-Dimethyl-1-piperazinyl]-3-pyridinecarboxylic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of ethyl 5-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinecarboxylate (D32) (800 mg, 3 mmol) in tetrahydrofuran (5 ml) was treated with 0.5M lithium hydroxide (12 ml, 6 mmol). The mixture was stirred at room temperature for 2 hours. The reaction was quenched with acetic acid (1 ml). The solvent was evaporated and the residue purified on SCX eluting with 2M ammonia in methanol to give the title compound (D33). MS (ES+) m/e 236 [M+H]+.

後処理

  1. customThe reaction was quenched with acetic acid (1 ml)
  2. customThe solvent was evaporated
  3. customthe residue purified on SCX
  4. washeluting with 2M ammonia in methanol

出典と根拠

ORDレコード
ord-47e7385d00a8420ea36b40ab580a86e5
出典データセット
uspto-grants-2010_05
特許番号
US07713978B2

反応ノート

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