Hydrochloric Acid → 2-Methyl-3-hydroxy-4-mercaptomethyl-5-vinylpyridine
反応式
[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][S:10]C(=O)C2C=CC=CC=2)[C:5]([CH:19]=[CH2:20])=[CH:4][N:3]=1.[OH-].[Na+].Cl.C(=O)(O)[O-].[Na+]>O1CCCC1>[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][SH:10])[C:5]([CH:19]=[CH2:20])=[CH:4][N:3]=1参加物
6
実験手順
A mixture of 1 g. of 2-methyl-3-hydroxy-4-benzoylthiomethyl-5-vinylpyridine, 10 ml. of tetrahydrofuran, and 10 ml. of 2.5 N aqueous sodium hydroxide was aged at room temperature overnight. The solution was acidified to about pH 6 with hydrochloric acid and then adjusted to pH 7.5 with solid sodium bicarbonate. The mixture was extracted with 3×100 ml. of ethyl acetate: isopropanol (9:1 v/v). The extract was dried over magnesium sulfate and concentrated to give 2-methyl-3-hydroxy-4-mercaptomethyl-5-vinylpyridine.
後処理
- additionA mixture of 1 g
- extractionThe mixture was extracted with 3×100 ml
- dry with materialThe extract was dried over magnesium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-dd3ea34457d44026895d9b206d15df1e
- 出典データセット
- uspto-grants-1982_10
- 特許番号
- US04355034
反応ノート
読み込み中…