Triethylamine → 2-(Chloromethyl)-5-(4-(trifluoromethyl)phenyl)thiophene

HRID 2235647

反応式

HRID 2235647 の反応式
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]([CH2:14]O)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.C(N(CC)CC)C.S(Cl)([Cl:27])=O>C(Cl)Cl>[Cl:27][CH2:14][C:12]1[S:13][C:9]([C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:17])([F:16])[F:1])=[CH:4][CH:5]=2)=[CH:10][CH:11]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 219863522-Thiophenemethanol, 5-[4-(trifluoromethyl)phenyl]-

生成物 1

HCID 575949792-(Chloromethyl)-5-(4-(trifluoromethyl)phenyl)thiophene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 61.3 (45 mg, 0.18 mmol) in DCM (0.9 mL) were added triethylamine (24 μL, 0.18 mmol) and thionyl chloride (19 μL, 0.26 mmol) at room temperature. The mixture was stirred overnight and concentrated to afford 61.4. The crude product was used without further purification.

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-107a5558379b4409853e9c706a2f125f
出典データセット
uspto-grants-2010_05
特許番号
US07714008B2

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