Pyridine → 1H-Indole-6-carbaldehyde O-methyl-oxime

HRID 2236430

反応式

HRID 2236430 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH:10]=O)[CH:8]=2)[CH:3]=[CH:2]1.N1C=CC=CC=1.Cl.[O:19]([NH2:21])[CH3:20]>O>[CH3:20][O:19][N:21]=[CH:10][C:7]1[CH:8]=[C:9]2[C:4]([CH:3]=[CH:2][NH:1]2)=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 27734351H-Indole-6-carboxaldehyde

生成物 1

HCID 722508601H-Indole-6-carbaldehyde O-methyl-oxime収率 82.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

An amount of 1H-Indole-6-carbaldehyde (50 mg, 0.34 mmol) is added to pyridine (2.0 ml) at room temperature, followed by addition of methoxylamine hydrogen chloride (31.6 mg, 0.38 mmol). The mixture is stirred at ambient temperature for 24 h, and 10 mL of water is added. After the solvents were evaporated, the residue is dissolved 10 mL of anhydrous ether, washed successively with 10 mL of aqueous sodium bicarbonate, 10 mL of sodium bisulfite, and 10 mL of brine. Dried over magnesium sulfate, evaporated to give a white solid (49 mg, 0.281 mmol). MS (ESI) m/z 176.3 (M+1)

後処理

  1. customAfter the solvents were evaporated
  2. dissolutionthe residue is dissolved 10 mL of anhydrous ether
  3. washwashed successively with 10 mL of aqueous sodium bicarbonate, 10 mL of sodium bisulfite, and 10 mL of brine
  4. dry with materialDried over magnesium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-9755bd7b0d8e47f39496ab019f24d438
出典データセット
uspto-grants-2010_05
特許番号
US07713994B2

関連ノート

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