Triethylamine → 2-Bromo-N-(5-methyl-isoxazol-3-yl)-acetamide

HRID 2240292ノート

反応式

HRID 2240292 の反応式
[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH2:7])[CH:3]=1.C(N(CC)CC)C.[Br:15][CH2:16][C:17](Br)=[O:18]>C(Cl)(Cl)Cl>[Br:15][CH2:16][C:17]([NH:7][C:4]1[CH:3]=[C:2]([CH3:1])[O:6][N:5]=1)=[O:18]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 61147Bromoacetyl bromideHCID 661723-Amino-5-methylisoxazole

生成物 1

HCID 64850652-Bromo-N-(5-methyl-isoxazol-3-yl)-acetamide

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

反応条件

温度
-40 °C

実験手順

To a stirred solution of 5-methyl-isoxazol-3-ylamine (4.0 g, 40.8 mmol) and triethylamine (6.8 ml, 50 mmol) in chloroform (20 ml) cooled to −40° C., is added bromoacetyl bromide (3.9 ml, 44.9 mmol) in chloroform (20 ml). The reaction mixture is stirred at −40° C. for 30 minutes and then allowed to warm to room temperature. The resultant suspension is filtered, washed with DCM and dried in vacuo to yield the titled compound.

後処理

  1. temperatureto warm to room temperature
  2. filtrationThe resultant suspension is filtered
  3. washwashed with DCM
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-e1cfa6179eae4288a4def748a48c1cf0
出典データセット
uspto-grants-2010_05
特許番号
US07723356B2

反応ノート

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