Sodium Hydroxide → HCID 68480823、化合物

HRID 2240555ノート

反応式

HRID 2240555 の反応式
[OH-].[Na+:2].ClC1C=CC(S(C2C3C(=CC=C(C)C=3)N(CC(O)=O)C=2C)(=O)=O)=CC=1.[Cl:28][C:29]1[C:30](C#N)=[C:31]2[C:35](=[CH:36][CH:37]=1)[N:34]([CH2:38][C:39]([O:41]C)=[O:40])[C:33]([CH3:43])=[C:32]2[S:44]([C:47]1[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][CH:48]=1)(=[O:46])=[O:45]>C1COCC1>[Cl:28][C:29]1[CH:30]=[C:31]2[C:35](=[CH:36][CH:37]=1)[N:34]([CH2:38][C:39]([O-:41])=[O:40])[C:33]([CH3:43])=[C:32]2[S:44]([C:47]1[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][CH:48]=1)(=[O:45])=[O:46].[Na+:2]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 104072752-[3-(4-chlorophenyl)sulfonyl-2,5-dimethylindol-1-yl]acetic acidHCID 86605157HCID 86605157、化合物

生成物 1

HCID 68480823HCID 68480823、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Sodium hydroxide (1M, 4.3 ml) was added to a solution of the product of example 1 part (c) (1.75 g) in THF (60 ml). The reaction mixture was stirred overnight and then concentrated in vacuo. The residue was recrystallised from water to give the title compound as a white solid.

後処理

  1. concentrationconcentrated in vacuo
  2. customThe residue was recrystallised from water

出典と根拠

ORDレコード
ord-649e2d82c664437ca5b7fcb7cb8878f8
出典データセット
uspto-grants-2010_05
特許番号
US07723373B2

反応ノート

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