Water → 1-(Benzo[d]oxazol-2-yl)cyclopropanecarboxylic acid

HRID 2241358ノート

反応式

HRID 2241358 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1([C:13]([O:15]C)=[O:14])[CH2:12][CH2:11]1.C1COCC1.O.[Li+].[OH-]>C(OCC)(=O)C>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]1

参加物

6

反応物 4

HCID 962WaterHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 68518116Methyl 1-(benzo[d]oxazol-2-yl)cyclopropanecarboxylate

生成物 1

HCID 685133131-(Benzo[d]oxazol-2-yl)cyclopropanecarboxylic acid収率 81%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a stirred solution of methyl 1-(benzo[d]oxazol-2-yl)cyclopropanecarboxylate (0.132 g, 0.6077 mmol) in 3 mL 3:2 THF:H2O at room temperature under nitrogen was added LiOH (0.02911 g, 1.215 mmol). After stirring at ambient temperature overnight the reaction was diluted to 30 mL with ethyl acetate and washed with 2N HCl, water and brine. The organics were dried (MgSO4), filtered and concentrated to a white solid (100 mg, 81% yield).

後処理

  1. washwashed with 2N HCl, water and brine
  2. dry with materialThe organics were dried (MgSO4)
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-15b1df92e5eb48e2a9410c3b1482d797
出典データセット
uspto-grants-2010_05
特許番号
US07723330B2

反応ノート

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