Diethyl Malonate → Diethyl isopentylmalonate

HRID 22417

反応式

HRID 22417 の反応式
[Na].[C:2]([O:10][CH2:11][CH3:12])(=[O:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[O-]CC.[Na+:16].[CH2:17](Br)[CH2:18][CH:19]([CH3:21])[CH3:20]>C(O)C>[O-:5][CH2:4][CH3:3].[Na+:16].[CH2:17]([CH:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:2]([O:10][CH2:11][CH3:12])=[O:9])[CH2:18][CH:19]([CH3:21])[CH3:20]

参加物

7

反応物 4

HCID 7761Diethyl MalonateHCID 78911-Bromo-3-methylbutaneHCID 2723922Sodium ethoxideHCID 5360545Sodium

生成物 2

HCID 79384Diethyl isopentylmalonateHCID 2723922Sodium ethoxide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Sodium ethoxide was prepared from sodium metal (9.1 g) and freshly distilled absolute ethanol (250 ml). Diethyl malonate (63.5 g) was added to sodium ethoxide in ethanol, and the mixture was stirred at 60°-70° C. for 50 min. Isoamyl bromide (60 g) was added, and the reaction mixture was heated under reflux overnight. After the usual work-up, the resulting crude product was distilled under reduced pressure to give diethyl isoamylmalonate. Yield: 71.7 g (78%).

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux overnight
  3. distillationAfter the usual work-up, the resulting crude product was distilled under reduced pressure

出典と根拠

ORDレコード
ord-ba34f5f565a642ce817fb30dcee7b722
出典データセット
uspto-grants-1995_06
特許番号
US05428062

関連ノート

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