2-Amino-5-methylbenzoic acid → 2-Carboxy-4-methylcyclohexan-1-yl-amine
反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[H][H]>O1CCCC1.[Ru].C>[C:4]([CH:3]1[CH2:7][CH:8]([CH3:11])[CH2:9][CH2:10][CH:2]1[NH2:1])([OH:6])=[O:5]参加物
5
実験手順
50 g (0.33 mol) of 2-amino-5-methyl-benzoic acid, dissolved in 100 ml of tetrahydrofuran, are hydrogenated for 14 hours at 200° C. and 200 bar hydrogen in the presence of 5 g of ruthenium/charcoal. After cooling and evaporation, 30 g o f 2-carboxy-4-methyl-cyclohexan-1-yl -amine are obtained as a pale oil.
後処理
- temperatureAfter cooling
- customevaporation, 30 g o f 2-carboxy-4-methyl-cyclohexan-1-yl -amine
- customare obtained as a pale oil
出典と根拠
- ORDレコード
- ord-7803faf4114942328d46e35a1e9d6188
- 出典データセット
- uspto-grants-1995_06
- 特許番号
- US05428073
反応ノート
読み込み中…