Ethanol → Ethyl 3-amino-2-methylpropanoate hydrochloride

HRID 2242386ノート

反応式

HRID 2242386 の反応式
[NH2:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5].S(Cl)([Cl:10])=O.[CH2:12](O)[CH3:13]>C(Cl)Cl>[ClH:10].[CH2:12]([O:5][C:4](=[O:6])[CH:3]([CH3:7])[CH2:2][NH2:1])[CH3:13]

参加物

5

反応物 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 64956Beta-Aminoisobutyric Acid

生成物 1

HCID 19611788Ethyl 3-amino-2-methylpropanoate hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
50 °C

実験手順

3-Aminoisobutyric acid (1.00 g, 9.7 mmol) was stirred in DCM under nitrogen and thionyl chloride (1.4 ml, 19.4 mmol) was added at room temperature. The reaction was heated to 50° C. for 2 h. The solvent and any excess thionyl chloride were removed under reduced pressure and the oil obtained was dissolved in ethanol (20 ml) stirring at room temperature for 18 h. The solvent was removed under reduced pressure to give 3-aminoisobutyric acid ethyl ester hydrochloride as a viscous, cloudy oil (1.47 g, 90%).

後処理

  1. customThe solvent and any excess thionyl chloride were removed under reduced pressure
  2. customthe oil obtained
  3. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-6b0fbca56b8d462aa450a7993f682fa6
出典データセット
uspto-grants-2010_03
特許番号
US07671080B2

反応ノート

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