Phenacyl bromide → 1-(5-Bromo-4-(4-phenylthiazol-2-yl)pyridin-2-yl)-3-ethylurea

HRID 2243076ノート

反応式

HRID 2243076 の反応式
[Br:1][C:2]1[C:3]([C:14](=[S:16])[NH2:15])=[CH:4][C:5]([NH:8][C:9]([NH:11][CH2:12][CH3:13])=[O:10])=[N:6][CH:7]=1.Br[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=O>C(#N)C>[Br:1][C:2]1[C:3]([C:14]2[S:16][CH:18]=[C:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:15]=2)=[CH:4][C:5]([NH:8][C:9]([NH:11][CH2:12][CH3:13])=[O:10])=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 6259Phenacyl bromideHCID 59208439AZD7118 Bromo Thioamide2 回

生成物 1

HCID 592085041-(5-Bromo-4-(4-phenylthiazol-2-yl)pyridin-2-yl)-3-ethylurea収率 84.7%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a mixture of 5-bromo-2-(3-ethylureido)pyridine-4-carbothioamide (Intermediate 42, 0.146 g, 0.48 mmol) in acetonitrile (3 mL), 2-bromo-1-phenylethanone (0.105 g, 0.53 mmol) was added and the reaction mixture was heated to 80° for 16 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The resulting solids were filtered and washed with acetonitrile to yield 164 mg of the title compound as an off-white solid.

後処理

  1. additionwas added
  2. temperaturethe reaction mixture was heated to 80° for 16 h
  3. concentrationconcentrated under reduced pressure
  4. filtrationThe resulting solids were filtered
  5. washwashed with acetonitrile

出典と根拠

ORDレコード
ord-5f795704f2194ca29e815cfebf151739
出典データセット
uspto-grants-2010_03
特許番号
US07674801B2

反応ノート

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