HCID 10999447、化合物 → 2-Phenylquinolin-6-amine

HRID 2243082ノート

反応式

HRID 2243082 の反応式
[C:1]1([C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([N+:17]([O-])=O)[CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C1COCC1.CO.[Pd]>[C:1]1([C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([NH2:17])[CH:13]=3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 1

HCID 10999447HCID 10999447、化合物

生成物 1

HCID 171481752-Phenylquinolin-6-amine

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Pd/C (10%; 0.60 g) is added to 2-phenyl-6-nitroquinoline (7 g, 0.028 mol) in THF (300 ml) and methanol (300 ml). The mixture is hydrogenated at room temperature and at 1 atm. The catalyst is filtered off, the filtrate is evaporated and the product is recrystallized from isopropyl ether. Yield: 5.7 g (92%); Rf (9/1 chloroform/methanol): 0.56; IR (KBr): 3455, 3320, 3205, 1625, 1495 cm−1.

後処理

  1. customis hydrogenated at room temperature and at 1 atm
  2. filtrationThe catalyst is filtered off
  3. customthe filtrate is evaporated
  4. customthe product is recrystallized from isopropyl ether

出典と根拠

ORDレコード
ord-30c50a19a791453b89a8ecac714bc420
出典データセット
uspto-grants-2010_03
特許番号
US07674809B2

反応ノート

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