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Sodium hydride → N-Cyclopropyl-3-fluoro-4-methyl-5-[1-(tetrahydro-2H-pyran-2-ylmethyl)-1H-indazol-5-yl]benzamide

HRID 2246629
ノート
印刷プレビュー

反応式

HRID 2246629 の反応式
[H-].[Na+].[CH:3]1([NH:6][C:7](=[O:25])[C:8]2[CH:13]=[C:12]([C:14]3[CH:15]=[C:16]4[C:20](=[CH:21][CH:22]=3)[NH:19][N:18]=[CH:17]4)[C:11]([CH3:23])=[C:10]([F:24])[CH:9]=2)[CH2:5][CH2:4]1.Br[CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][O:29]1>CN(C=O)C.C(Cl)(Cl)Cl.C(OCC)(=O)C>[CH:3]1([NH:6][C:7](=[O:25])[C:8]2[CH:13]=[C:12]([C:14]3[CH:15]=[C:16]4[C:20](=[CH:21][CH:22]=3)[N:19]([CH2:27][CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][O:29]3)[N:18]=[CH:17]4)[C:11]([CH3:23])=[C:10]([F:24])[CH:9]=2)[CH2:4][CH2:5]1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 3

HCID 24758Sodium hydrideHCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 10403067N-Cyclopropyl-3-fluoro-5-(1H-indazol-5-yl)-4-methylbenzamide2 回

生成物 1

HCID 11292707N-Cyclopropyl-3-fluoro-4-methyl-5-[1-(tetrahydro-2H-pyran-2-ylmethyl)-1H-indazol-5-yl]benzamide

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒
HCID 21584013
Chloroform ethylacetate
溶媒

実験手順

Sodium hydride (60% in mineral oil, 12 mg) was added to N-cyclopropyl-3-fluoro-5-(1H-indazol-5-yl)-4-methylbenzamide (Intermediate 3, 45 mg) in DMF (5 ml) and the mixture was stirred at room temperature for 1 h. 2-(Bromomethyl)tetrahydro-2H-pyran (20.5 μl) was added and stirring continued for 18 h. The mixture was diluted with chloroform/ethyl acetate (1:1, 5 ml) and washed with water (2×5 ml). The organic phase was concentrated under vacuum and the residue was purified by preparative HPLC to give the title compound as a colourless glass (23 mg).

後処理

  1. stirringstirring
  2. waitcontinued for 18 h
  3. washwashed with water (2×5 ml)
  4. concentrationThe organic phase was concentrated under vacuum
  5. customthe residue was purified by preparative HPLC

出典と根拠

ORDレコード
ord-1229b14028bb485c805ddc8e30b838cf
出典データセット
uspto-grants-2010_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07687532B2

反応ノート

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