N-bromobutanimide → 5-Bromo-2,3-dihydro-1-benzofuran

HRID 2247416ノート

反応式

HRID 2247416 の反応式
COC(/C=C/[C:7]1[CH:12]=[C:11](O)[C:10]2[O:14][CH:15](C3C=CC(O)=C(O)C=3)[CH:16](C(OC)=O)[C:9]=2[CH:8]=1)=O.[Br:29]N1C(=O)CCC1=O>C(#N)C>[Br:29][C:7]1[CH:12]=[CH:11][C:10]2[O:14][CH2:15][CH2:16][C:9]=2[CH:8]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 5857314Dihydrobezofuran

生成物 1

HCID 27761595-Bromo-2,3-dihydro-1-benzofuran収率 331.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Dihydrobenzofuran (9.34 g) was dissolved in 130 ml of acetonitrile, 13.9 g of N-bromosuccinimide was added thereto and the mixture was stirred at room temperature for 3 hours. The solvent was evaporated, then the residue was dissolved in ethyl acetate and successively washed with water and brine. The organic layer was dried over anhydrous magnesium sulfate and the solvent was removed, to give 15.94 g of the title compound.

後処理

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washsuccessively washed with water and brine
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. customthe solvent was removed

出典と根拠

ORDレコード
ord-549d7ac1e7cd483fa564e3b97750a56c
出典データセット
uspto-grants-2010_03
特許番号
US07687664B2

反応ノート

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