Water → 4-Aminocoumarin

HRID 224747

反応式

HRID 224747 の反応式
O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[O:5][C:4](=[O:12])[CH:3]=1.C([O-])(=O)C.[NH4+:17].O>C(O)CO>[NH2:17][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[O:5][C:4](=[O:12])[CH:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 517165Ammonium AcetateHCID 546829304-Hydroxycoumarin

生成物 1

HCID 8208074-Aminocoumarin収率 99.4%

試薬・触媒・溶媒 1

HCID 174Ethylene Glycol溶媒

反応条件

温度
60 °C

実験手順

97.2 g of 4-hydroxycoumarin and 69.3 g of ammonium acetate in 300 ml of ethylene glycol are heated to 70° C. for 3 hours, whilst stirring, and to 160° C. for 6 hours, the mixture is cooled to 60° C., 1 liter of water is added, whilst stirring, and the mixture is cooled to room temperature. The colourless crystalline precipitate is filtered off, washed with water and dried in vacuo at 60° C. 96 g of 4-aminocoumarin in an almost pure form are obtained.

後処理

  1. stirringwhilst stirring
  2. temperaturethe mixture is cooled to room temperature
  3. filtrationThe colourless crystalline precipitate is filtered off
  4. washwashed with water
  5. customdried in vacuo at 60° C

出典と根拠

ORDレコード
ord-a991ef93bd7c452db36474033f77f721
出典データセット
uspto-grants-1980_11
特許番号
US04234488

関連ノート

読み込み中…