Dimethylformamide → (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl chloride

In 30.0 ml of 1,2-dimethoxyethane (DME), 10.0 g of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-methoxyiminoacetic acid were stirred at -20° C., followed by the dropwise addition of a chlorinating reagent, which had been prepared beforehand by gradually adding 6.97 g of oxalyl chloride at 5° C. to a mixture of 100 ml of DME and 4.0 g of N,N-dimethylformamide (DMF) and then reacting them for 30 minutes. After they were reacted for 5 minutes, the reaction mixture was poured into 200 ml of ice water to precipitate crystals. The crystals were collected by filtration, washed with 100 ml of ice water, collected by filtration and then, stirred for 30 minutes in 100 ml of n-hexane. After filtration, the resulting crystals were dried under reduced pressure, whereby the title compound was obtained. Yield: 8.2 g (75.1%). Purity: 94.1%.

1. additionfollowed by the dropwise addition of a chlorinating reagent, which
2. customhad been prepared beforehand
3. customfor 30 minutes
4. customAfter they were reacted for 5 minutes
5. customto precipitate crystals
6. filtrationThe crystals were collected by filtration
7. washwashed with 100 ml of ice water
8. filtrationcollected by filtration
9. filtrationAfter filtration
10. dry with materialthe resulting crystals were dried under reduced pressure, whereby the title compound
11. customwas obtained

ORDレコード

ord-06bcacbc5f36498ca0864d64b87bbffb

出典データセット

uspto-grants-1995_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05428173