Water → 3-(4-Amino-3-nitrophenyl)-1-phenyl-2-propen-1-one

HRID 2247863

反応式

HRID 2247863 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[OH-].[Na+].C([NH:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][C:17]=1[N+:24]([O-:26])=[O:25])(=O)C.O>C(O)C>[NH2:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[CH:2][C:1]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[O:3])=[CH:18][C:17]=1[N+:24]([O-:26])=[O:25]

参加物

6

反応物 4

HCID 962WaterHCID 7410AcetophenoneHCID 14798Sodium HydroxideHCID 291355N-(4-formyl-2-nitrophenyl)acetamide

生成物 1

HCID 537490733-(4-Amino-3-nitrophenyl)-1-phenyl-2-propen-1-one収率 94.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of acetophenone (7.2 g) and 4N-sodium hydroxide solution (14 ml) in ethanol (50 ml) was added 4-acetylamino-3-nitrobenzaldehyde (10.4 g) at ambient temperature under stirring and the resultant mixture was stirred at same condition for 2 hours. To the reaction mixture was added water and precipitate was collected by filtration. The precipitate was suspended in water (300 ml) and the resultant mixture was adjusted to pH 4.0 with 10% hydrochloric acid. The precipitate was collected by filtration and washed with brine and dried to give 3-(4-amino-3-nitrophenyl)-1-phenyl-2-propen-1-one (12.7 g).

後処理

  1. filtrationwas collected by filtration
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with brine
  4. customdried

出典と根拠

ORDレコード
ord-02687328fc6f4df0b0f9d98ad9925211
出典データセット
uspto-grants-1991_08
特許番号
US05037824

関連ノート

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