Acetic Acid → Indole, 5-bromo-3-(dimethylamino)methyl-

HRID 224895

反応式

HRID 224895 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.C=O.[CH3:13][NH:14][CH3:15].[C:16](O)(=O)C>O1CCOCC1>[CH3:13][N:14]([CH2:16][C:5]1[C:4]2[CH:3]=[C:2]([Br:1])[CH:10]=[CH:9][C:8]=2[NH:7][CH:6]=1)[CH3:15]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 674DimethylamineHCID 712FormaldehydeHCID 249055-Bromoindole

生成物 1

HCID 13249Indole, 5-bromo-3-(dimethylamino)methyl-

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

This material was prepared by the method of Procedure 67B from 49.5 g. of 5-bromoindole, 20 ml. of 37% aqueous formaldehyde, 55 ml. of 25% aqueous dimethylamine, 250 ml. of acetic acid and 250 ml. of dioxane; yield 60.6 g., m.p. 154°-156° C. The structure was confirmed by examination of the NMR spectrum.

後処理

  1. customThis material was prepared by the method of Procedure 67B from 49.5 g

出典と根拠

ORDレコード
ord-b8d02287528a42eeb37d82ed1423ce24
出典データセット
uspto-grants-1980_11
特許番号
US04234595

関連ノート

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