Hydrazine hydrate (1:1) → Indole, 3-(2-amino-2-methylpropyl)-5-bromo-

HRID 224897

反応式

HRID 224897 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]([CH3:17])([N+:14]([O-])=O)[CH3:13].O.NN>[Ni+2]>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]([CH3:17])([CH3:13])[NH2:14]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 126196615-Bromo-3-(2-methyl-2-nitropropyl)indole

生成物 1

HCID 13259Indole, 3-(2-amino-2-methylpropyl)-5-bromo-

試薬・触媒・溶媒 1

HCID 934Nickel cation触媒

実験手順

5-Bromo-3-(2-methyl-2-nitropropyl)indole, 5.9 g. was reduced with Raney nichel and hydrazine hydrate according to the method of Procedure 67D. The crude product was purified by dissolving in 200 ml. of dilute hydrochloric acid, treatment with activated charcoal, filtering, and basification of the filtrate with 10% aqueous sodium hydroxide. Yield 3.8 g. of white powder, m.p. 150°-155° C.

後処理

  1. customThe crude product was purified
  2. dissolutionby dissolving in 200 ml
  3. filtrationof dilute hydrochloric acid, treatment with activated charcoal, filtering

出典と根拠

ORDレコード
ord-1e15576f9e24402ea73d6f066ceafe14
出典データセット
uspto-grants-1980_11
特許番号
US04234595

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