反応式
[OH-].[Na+].C(N[CH2:7][C:8]1[S:12][C:11]([CH2:13][C:14]([OH:16])=[O:15])=[CH:10][CH:9]=1)(=O)C.[C:17]([O:21][C:22]([N:24]=[N+]=[N-])=[O:23])([CH3:20])([CH3:19])[CH3:18]>O1CCOCC1>[C:17]([O:21][C:22]([NH:24][CH2:7][C:8]1[S:12][C:11]([CH2:13][C:14]([OH:16])=[O:15])=[CH:10][CH:9]=1)=[O:23])([CH3:20])([CH3:19])[CH3:18]参加物
5
反応条件
- 温度
- 25 °C
実験手順
0.3 ml of a 2 N aqueous sodium hydroxide solution is added to a solution of 0.6 g of 2-(5-acetylaminomethyl-2-thienyl)-acetic acid in 5 ml of dioxane. The mixture is stirred for 12 hours at 55°-60° C. and cooled to 25° C., 0.2 ml of tert.-butoxycarbonyl azide is added, the mixture is stirred for 16 hours at room temperature and 2-(5-tert.-butoxycarbonylaminomethyl-2-thienyl)-acetic acid is isolated in accordance with the process described above.
後処理
- stirringthe mixture is stirred for 16 hours at room temperature
出典と根拠
- ORDレコード
- ord-e16cd6a4384745fe8755233708ca10f0
- 出典データセット
- uspto-grants-1980_11
- 特許番号
- US04234578
関連ノート
読み込み中…