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Hydrochloric Acid → 3-[5-(3,5-Diisobutoxybenzoyl)-2-isobutoxyphenyl]propanoic acid

HRID 2249630
ノート
印刷プレビュー

反応式

HRID 2249630 の反応式
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH:29]=[C:30]([O:32][CH2:33][CH:34]([CH3:36])[CH3:35])[CH:31]=1)[C:9]([C:11]1[CH:12]=[CH:13][C:14]([O:24][CH2:25][CH:26]([CH3:28])[CH3:27])=[C:15]([CH2:17][CH2:18][C:19]([O:21]CC)=[O:20])[CH:16]=1)=[O:10])[CH:2]([CH3:4])[CH3:3].[OH-].[Na+].C(Cl)(Cl)Cl.Cl>C(O)C.O>[CH2:33]([O:32][C:30]1[CH:29]=[C:8]([CH:7]=[C:6]([O:5][CH2:1][CH:2]([CH3:4])[CH3:3])[CH:31]=1)[C:9]([C:11]1[CH:12]=[CH:13][C:14]([O:24][CH2:25][CH:26]([CH3:27])[CH3:28])=[C:15]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:16]=1)=[O:10])[CH:34]([CH3:36])[CH3:35]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 17816456Ethyl 3-[5-(3,5-diisobutoxybenzoyl)-2-isobutoxyphenyl]propanoate

生成物 1

HCID 576844023-[5-(3,5-Diisobutoxybenzoyl)-2-isobutoxyphenyl]propanoic acid収率 93.2%

試薬・触媒・溶媒 2

HCID 702
Ethanol
溶媒
HCID 962Water溶媒

実験手順

In 9 ml of ethanol is dissolved 1.74 g of ethyl 3-[5-(3,5-diisobutoxybenzoyl)-2-isobutoxyphenyl]-propanoate. After adding 2 ml of 5 mol/L solution of sodium hydroxide, the mixture thus obtained is stirred at ambient temperature for one hour. Chloroform and water are added to the reaction mixture, pH is adjusted to 2 with 6 mol/L hydrochloric acid, and the organic layer is separated. The organic layer is successively washed with water and saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate, and the solvent is distilled off under reduced pressure. Thus, 1.53 g of 3-[5-(3,5-diisobutoxybenzoyl)-2-isobutoxyphenyl]propanoic acid is obtained as a white solid product.

後処理

  1. customthe mixture thus obtained
  2. customthe organic layer is separated
  3. washThe organic layer is successively washed with water and saturated aqueous solution of sodium chloride
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationthe solvent is distilled off under reduced pressure

出典と根拠

ORDレコード
ord-37b51e593b7c4ddd8bae7b2d0bf1b3fd
出典データセット
uspto-grants-2008_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07314888B1

反応ノート

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