Hydrochloric Acid → (2,4-Diisobutoxyphenyl)(3-hydroxy-4-isobutoxyphenyl)methanone

HRID 2249636ノート

反応式

HRID 2249636 の反応式
C([O:4][C:5]1[CH:10]=[C:9]([C:11](=[O:28])[C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH:20]([CH3:22])[CH3:21])=[CH:14][C:13]=2[O:23][CH2:24][CH:25]([CH3:27])[CH3:26])[CH:8]=[CH:7][C:6]=1[O:29][CH2:30][CH:31]([CH3:33])[CH3:32])(=O)C.[OH-].[Na+].O.Cl>C(O)C.C(Cl)(Cl)Cl>[CH2:24]([O:23][C:13]1[CH:14]=[C:15]([O:18][CH2:19][CH:20]([CH3:22])[CH3:21])[CH:16]=[CH:17][C:12]=1[C:11]([C:9]1[CH:8]=[CH:7][C:6]([O:29][CH2:30][CH:31]([CH3:33])[CH3:32])=[C:5]([OH:4])[CH:10]=1)=[O:28])[CH:25]([CH3:27])[CH3:26]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 178164575-(2,4-Diisobutoxybenzoyl)-2-isobutoxyphenyl acetate

生成物 1

HCID 17816454(2,4-Diisobutoxyphenyl)(3-hydroxy-4-isobutoxyphenyl)methanone収率 91.8%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 6212Chloroform溶媒

実験手順

In 10 ml of ethanol is dissolved 0.48 g of 5-(2,4-diisobutoxybenzoyl)-2-isobutoxyphenyl acetate, to which is added 3.2 ml of 1 mol/L solution of sodium hydroxide. The mixture thus obtained is stirred at ambient temperature for one hour. Water and chloroform are added to the reaction mixture, pH is adjusted to 2 with 6 mol/L hydrochloric acid, and the organic layer is separated. The organic layer is washed with water and saturated aqueous solution of sodium chloride successively and dried on anhydrous magnesium sulfate, and the solvent is distilled off under reduced pressure. Thus, 0.40 g of (2,4-diisobutoxyphenyl)(3-hydroxy-4-isobutoxyphenyl)methanone is obtained as a light yellow solid product.

後処理

  1. customThe mixture thus obtained
  2. customthe organic layer is separated
  3. washThe organic layer is washed with water and saturated aqueous solution of sodium chloride successively
  4. dry with materialdried on anhydrous magnesium sulfate
  5. distillationthe solvent is distilled off under reduced pressure

出典と根拠

ORDレコード
ord-e8168b79f6564e9fa2b70a1b0657c971
出典データセット
uspto-grants-2008_01
特許番号
US07314888B1

反応ノート

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