Hydrochloric Acid → 3,5-Diisobutoxybenzoic acid

HRID 2249684ノート

反応式

HRID 2249684 の反応式
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH:16]=[C:17]([O:19][CH2:20][CH:21]([CH3:23])[CH3:22])[CH:18]=1)[C:9]([O:11]CC(C)C)=[O:10])[CH:2]([CH3:4])[CH3:3].[OH-].[Na+].C(Cl)(Cl)Cl.Cl>CO.O>[CH2:20]([O:19][C:17]1[CH:16]=[C:8]([CH:7]=[C:6]([O:5][CH2:1][CH:2]([CH3:4])[CH3:3])[CH:18]=1)[C:9]([OH:11])=[O:10])[CH:21]([CH3:23])[CH3:22]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 17816465Isobutyl 3,5-diisobutoxybenzoate

生成物 1

HCID 178165213,5-Diisobutoxybenzoic acid収率 87.2%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

In 13 ml of methanol is dissolved 2.5 g of isobutyl 3,5-diisobutoxybenzoate, to which is then added 2.3 ml of 5 mol/L sodium hydroxide solution. The mixture thus obtained is stirred at 50° C. for 3 hours. Chloroform and water are added to the reaction mixture, pH is adjusted to 2 with 6 mol/L hydrochloric acid, and the organic layer is separated. The organic layer is washed with water and saturated aqueous solution of sodium chloride successively and dried over anhydrous magnesium sulfate, and then the solvent is distilled off under reduced pressure. Thus, 1.8 g of 3,5-diisobutoxybenzoic acid is obtained as a white solid product.

後処理

  1. customThe mixture thus obtained
  2. customthe organic layer is separated
  3. washThe organic layer is washed with water and saturated aqueous solution of sodium chloride successively
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationthe solvent is distilled off under reduced pressure

出典と根拠

ORDレコード
ord-de732816561e4a21a0495977400ad866
出典データセット
uspto-grants-2008_01
特許番号
US07314888B1

反応ノート

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