Hydrochloric Acid → 1-(6-Chloro-benzo[b]thiophen-2-ylmethyl)-5-(2-methoxy-ethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

HRID 2250447ノート

反応式

HRID 2250447 の反応式
[Li+].[OH-].C([O:5][C:6]([C:8]1[N:21]([CH2:22][C:23]2[S:27][C:26]3[CH:28]=[C:29]([Cl:32])[CH:30]=[CH:31][C:25]=3[CH:24]=2)[C:11]2=[CH:12][N:13]=[C:14]([O:16][CH2:17][CH2:18][O:19][CH3:20])[CH:15]=[C:10]2[CH:9]=1)=[O:7])C.Cl>O.C1COCC1.CO>[Cl:32][C:29]1[CH:30]=[CH:31][C:25]2[CH:24]=[C:23]([CH2:22][N:21]3[C:11]4=[CH:12][N:13]=[C:14]([O:16][CH2:17][CH2:18][O:19][CH3:20])[CH:15]=[C:10]4[CH:9]=[C:8]3[C:6]([OH:7])=[O:5])[S:27][C:26]=2[CH:28]=1

参加物

7

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 692267011-(6-Chloro-benzo[b]thiophen-2-ylmethyl)-5-(2-methoxy-ethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester

生成物 1

HCID 692268441-(6-Chloro-benzo[b]thiophen-2-ylmethyl)-5-(2-methoxy-ethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

8 mL of a 1M LiOH solution in water were added to solution of 890 mg (2 mmol) 1-(6-Chloro-benzo[b]thiophen-2-ylmethyl)-5-(2-methoxy-ethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester in 30 mL THF and 15 mL MeOH and the mixture was stirred for 1 h at 50° C. 16 mL of 1N HCl were added, the organic solvent removed in vacuo and the residue extracted with ethyl acetate. The organic phase was dried over MgSO4. After filtration the solvent was evaporated yielding the desired product. Yield: 810 mg.

後処理

  1. customthe organic solvent removed in vacuo
  2. extractionthe residue extracted with ethyl acetate
  3. dry with materialThe organic phase was dried over MgSO4
  4. filtrationAfter filtration the solvent
  5. customwas evaporated

出典と根拠

ORDレコード
ord-dc4a66ec97444ac8ab1e15d98774a983
出典データセット
uspto-grants-2008_01
特許番号
US07317027B2

反応ノート

読み込み中…