Trifluoroacetic acid → 3-Amino-5-(3-ethoxypropyl)-5H-dibenzo[a,d]cycloheptene

HRID 225048ノート

反応式

HRID 225048 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:11]=[CH:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[C:7]([CH2:17][CH2:18][CH2:19][O:20][CH2:21][CH3:22])(O)[C:6]=2[CH:23]=1.[BH4-].[Na+].FC(F)(F)C(O)=O>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:11]=[CH:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[CH:7]([CH2:17][CH2:18][CH2:19][O:20][CH2:21][CH3:22])[C:6]=2[CH:23]=1

参加物

4

反応物 3

HCID 6422Trifluoroacetic acidHCID 4311764Sodium borohydrideHCID 233288763-Amino-5-(3-ethoxypropyl)-5H-dibenzo[a,d]cyclohepten-5-ol

生成物 1

HCID 123351493-Amino-5-(3-ethoxypropyl)-5H-dibenzo[a,d]cycloheptene

実験手順

3-Amino-5-(3-ethoxypropyl)-5H-dibenzo[a,d]cyclohepten-5-ol (10 g., 0.032 mole) and sodium borohydride (12.3 g., 0.325 mole) are ground together in a mortar. The mixture is added in portions to 250 ml. of trifluoroacetic acid, cooled in ice, and stirred vigorously under a stream of nitrogen in an efficient fume hood. Upon completion of the addition, the mixture is stirred for 15 minutes and the bulk of the trifluoroacetic acid removed under vacuum.

後処理

  1. additionThe mixture is added in portions to 250 ml
  2. additionUpon completion of the addition
  3. stirringthe mixture is stirred for 15 minutes
  4. customthe bulk of the trifluoroacetic acid removed under vacuum

出典と根拠

ORDレコード
ord-31acb281c19242dd8919b06beaeef67f
出典データセット
uspto-grants-1980_11
特許番号
US04235820

反応ノート

読み込み中…