Benzyl chloroformate → Methyl 4-({[(benzyloxy)carbonyl]amino}sulfonyl)benzoate

HRID 2250559ノート

反応式

HRID 2250559 の反応式
[NH2:1][S:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].C(=O)([O-])[O-].[K+].[K+].[CH:21]1[CH:26]=[CH:25][C:24]([CH2:27][O:28][C:29](Cl)=[O:30])=[CH:23][CH:22]=1>C(COC)OC>[CH2:27]([O:28][C:29]([NH:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:13][CH:14]=1)(=[O:3])=[O:4])=[O:30])[C:24]1[CH:25]=[CH:26][CH:21]=[CH:22][CH:23]=1

参加物

5

反応物 3

HCID 10387Benzyl chloroformateHCID 11430Potassium CarbonateHCID 89847Methyl 4-sulphamoylbenzoate

生成物 1

HCID 57444531Methyl 4-({[(benzyloxy)carbonyl]amino}sulfonyl)benzoate収率 40.8%

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒2 回

実験手順

A mixture of methyl 4-(aminosulfonyl)benzoate (5.10 g) and potassium carbonate (655 g) in dimethoxyethane (50 mL) was refluxed for 5 minutes. After cooling the mixture, a solution of benzyl chloridocarbonate (5.25 g) in dimethoxyethane (30 mL), and the resulting mixture was refluxed for 1 hour. The reaction was quenched by adding 1N hydrochloric acid (100 mL). The mixture was extracted with ethyl acetate (200 mL), and the organic layer was washed with brine, dried over magnesium sulfate, and evaporated to give a pale yellow oil, which was solidified upon standing. The solid was triturated in diisopropyl ether (30 mL) to give methyl 4-({[(benzyloxy)carbonyl]amino}sulfonyl)benzoate as a white powder (3.38 g).

後処理

  1. temperaturewas refluxed for 5 minutes
  2. temperatureAfter cooling the mixture
  3. customThe reaction was quenched
  4. additionby adding 1N hydrochloric acid (100 mL)
  5. extractionThe mixture was extracted with ethyl acetate (200 mL)
  6. washthe organic layer was washed with brine
  7. dry with materialdried over magnesium sulfate
  8. customevaporated
  9. customto give a pale yellow oil, which
  10. customThe solid was triturated in diisopropyl ether (30 mL)

出典と根拠

ORDレコード
ord-3ff8e803fed646429f215a08aa3f1fdd
出典データセット
uspto-grants-2008_01
特許番号
US07317009B2

反応ノート

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