Triethylamine → 4-n-Hexyl-1-(5-hydroxypentyl)piperidine hydrochloride

HRID 225096

反応式

HRID 225096 の反応式
[CH2:1]([CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[Cl:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19].C(N(CC)CC)C.[OH-].[Na+]>C1(C)C=CC=CC=1>[ClH:13].[CH2:1]([CH:7]1[CH2:8][CH2:9][N:10]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[CH2:11][CH2:12]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 14798Sodium HydroxideHCID 789155-Chloro-1-pentanolHCID 190697874-Hexylpiperidine

生成物 1

HCID 233289164-n-Hexyl-1-(5-hydroxypentyl)piperidine hydrochloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Seventeen (17) grams of 4-n-hexylpiperidine, 13 grams of 5-chloropentanol and 11 grams of triethylamine were dissolved in 100 ml. of toluene. The solution is heated in an autoclave for twelve hours at 120°-140° Centigrade. The solution is stirred with 200 ml. of 5-N NaOH. The organic phase is separated, dried, the solvent evaporated and the base distilled at 130°-135° Centigrade/0.01 mm Hg. The yield is 17.5 grams. The hydrochloride is obtained in the usual manner, according to Example 1, and melts at 142°-145° Centigrade.

後処理

  1. temperatureThe solution is heated in an autoclave for twelve hours at 120°-140° Centigrade
  2. customThe organic phase is separated
  3. customdried
  4. customthe solvent evaporated
  5. distillationthe base distilled at 130°-135° Centigrade/0.01 mm Hg

出典と根拠

ORDレコード
ord-bce880627c704ece9144a6a2c0ab5d16
出典データセット
uspto-grants-1980_11
特許番号
US04235875

関連ノート

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