Sodium borohydride → 1-[2-Thienyl]-3-[1-(2-[1,4-benzodioxan-2-yl]-2-hydroxyethyl)piperid-4-yl]urea

HRID 225149ノート

反応式

HRID 225149 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][C:7]([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]([CH:19]2[O:24][C:23]3[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=3[O:21][CH2:20]2)=[O:18])[CH2:12][CH2:11]1)=[O:8].N1CCC(NC(NC2SC=CC=2)=O)CC1.BrCC(C1OC2C=CC=CC=2OC1)=O.[BH4-].[Na+]>CN(C=O)C.CCN(CC)CC.[OH-].[Na+]>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][C:7]([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH:17]([CH:19]2[O:24][C:23]3[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=3[O:21][CH2:20]2)[OH:18])[CH2:12][CH2:11]1)=[O:8]

参加物

7

反応物 4

HCID 4311764Sodium borohydrideHCID 126085852-Bromo-1-(2,3-dihydro-1,4-benzodioxin-2-yl)ethan-1-oneHCID 233290711-(Piperid-4-yl)-3-(2-thienyl)ureaHCID 233290751-[2-Thienyl]-3-[1-(2-[1,4-benzodioxan-2-yl]-2-oxoethyl)piperid-4-yl]urea

生成物 1

HCID 233290771-[2-Thienyl]-3-[1-(2-[1,4-benzodioxan-2-yl]-2-hydroxyethyl)piperid-4-yl]urea

試薬・触媒・溶媒 2

HCID 14798Sodium Hydroxide溶媒HCID 22056947triethylamine N,N-dimethylformamide溶媒

実験手順

1-[2-Thienyl]-3-[1-(2-[1,4-benzodioxan-2-yl]-2-oxoethyl)piperid-4-yl]urea, prepared by reacting 1-(piperid-4-yl)-3-(2-thienyl)urea with 2-bromoacetyl-1,4-benzodioxan in DMF/Et3N, may be reduced using sodium borohydride in 2 N sodium hydroxide to give the title compound.

出典と根拠

ORDレコード
ord-80ec1243b557497fb4553e67a7aaaf5a
出典データセット
uspto-grants-1980_11
特許番号
US04235915

反応ノート

読み込み中…