Thionyl Chloride → HCID 19744543、化合物

HRID 2254408ノート

反応式

HRID 2254408 の反応式
O[CH2:2][C:3]1[CH:4]=[C:5]([N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)[CH:6]=[CH:7][CH:8]=1.S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[Cl:16][CH2:2][C:3]1[CH:4]=[C:5]([N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 197444983-(1H-Imidazol-1-yl)benzenemethanol

生成物 1

HCID 19744543HCID 19744543、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

90 mg of 1-(3-hydroxymethylphenyl)imidazole was dissolved in 10 ml of chloroform, and 100 microliters of thionyl chloride was added. The mixture was stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure. The residue was dissolved in a mixture of ethyl ether and water. The organic layer was separated, washed successively with a 5% aqueous solution of sodium hydrogen carbonate and then with water, and dried over anhydrous magnesium sulfate. The desiccant was separated by filtration and then ethyl ether was evaporated to give 1-(3-chloromethylphenyl)imidazole as a pale yellow oily product.

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionThe residue was dissolved in a mixture of ethyl ether and water
  3. customThe organic layer was separated
  4. washwashed successively with a 5% aqueous solution of sodium hydrogen carbonate
  5. dry with materialwith water, and dried over anhydrous magnesium sulfate
  6. customThe desiccant was separated by filtration
  7. customethyl ether was evaporated

出典と根拠

ORDレコード
ord-6ee7d1e307c64f6fa8030df752486d9c
出典データセット
uspto-grants-1993_08
特許番号
US05234946

反応ノート

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