Benzyl Alcohol → Dibenzyl pyridine-2,5-dicarboxylate

反応式

[N:1]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[CH:4]=[CH:3][C:2]=1[C:10]([OH:12])=[O:11].S(Cl)(Cl)=O.[CH2:17](O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[N:1]1[CH:6]=[C:5]([C:7]([O:9][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:8])[CH:4]=[CH:3][C:2]=1[C:10]([O:12][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:11]

参加物

反応物 3

HCID 244Benzyl Alcohol

HCID 74932,5-Pyridinedicarboxylic acid

HCID 24386Thionyl Chloride

生成物 1

HCID 14210556Dibenzyl pyridine-2,5-dicarboxylate

実験手順

Analogously to Example 1, 20 g of pyridine-2,5-dicarboxylic acid are converted into the acid chloride with 160 m of thionyl chloride and this is reacted with 25.9 g of benzyl alcohol. The product is recrystallized from ethyl acetate, with the addition of active charcoal.