Water → (2 Aminoeth 1-yl) 4-naphth-1-ylpiperidine

HRID 2255444ノート

反応式

HRID 2255444 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].Cl.[C:8]1([CH:18]2[CH2:23][CH2:22][N:21]([CH2:24][C:25]#[N:26])[CH2:20][CH2:19]2)[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1.O.[OH-].[Na+]>O1CCCC1>[NH2:26][CH2:25][CH2:24][N:21]1[CH2:22][CH2:23][CH:18]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][CH:9]=2)[CH2:19][CH2:20]1

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 19784336(4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochlorideHCID 21226445Aluminium lithium hydride

生成物 1

HCID 19096243(2 Aminoeth 1-yl) 4-naphth-1-ylpiperidine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1.75 g of lithium aluminum hydride are added in fractions under a stream of nitrogen to a solution of 4.4 g of the compound from Example 4 in 150 ml of tetrahydrofuran. After stirring for 1 hour, the mixture is hydrolyzed with 1.75 ml of water, 3.5 ml of a 10% (wt/wt) sodium hydroxide solution and 7 ml of water. Filtration through celite, followed by evaporation of the solvent, yields an oily product which is used as it is in the following stage.

後処理

  1. filtrationFiltration through celite
  2. customfollowed by evaporation of the solvent
  3. customyields an oily product which

出典と根拠

ORDレコード
ord-cced53e66a3949e394ff8f2f8924ae07
出典データセット
uspto-grants-1993_08
特許番号
US05240942

反応ノート

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