Isopropylamine → Isopropylammonium 3-methyl-5-isothiazolecarboxylate

HRID 2255490ノート

反応式

HRID 2255490 の反応式
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[S:4][N:3]=1.[CH:10]([NH2:13])([CH3:12])[CH3:11]>O1CCCC1>[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([O-:9])=[O:8])[S:4][N:3]=1.[CH:10]([NH3+:13])([CH3:12])[CH3:11]

参加物

4

反応物 2

HCID 6363IsopropylamineHCID 2740923-Methyl-1,2-thiazole-5-carboxylic acid

生成物 1

HCID 19738253Isopropylammonium 3-methyl-5-isothiazolecarboxylate収率 85.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

3-Methyl-5-isothiazolecarboxylic acid (1.0 g) was dissolved in 10 ml of dry tetrahydrofuran, in which a solution of 0.41 g of isopropylamine in 5 ml of dry tetrahydrofuran were added dropwise at room temperature under stirring. White crystals were formed concurrently with the dropwise addition. After the reaction mixture was stirred further at room temperature for 30 minutes, crystals were collected by filtration and washed with a small amount of dry tetrahydrofuran. The crystals were dried at 40° C. for 3 hours under reduced pressure, whereby 1.20 g of the title compound were obtained (yield: 85%).

後処理

  1. additionwere added dropwise at room temperature
  2. customWhite crystals were formed concurrently with the dropwise addition
  3. stirringAfter the reaction mixture was stirred further at room temperature for 30 minutes
  4. filtrationcrystals were collected by filtration
  5. washwashed with a small amount of dry tetrahydrofuran
  6. customThe crystals were dried at 40° C. for 3 hours under reduced pressure

出典と根拠

ORDレコード
ord-f0a0db6f45a5443492cc50a77ba0e767
出典データセット
uspto-grants-1993_08
特許番号
US05240951

反応ノート

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