Sodium Hydroxide → Ethyl 2,7-diazabicyclo[3.3.0]octane-2-carboxylate

HRID 2255685ノート

反応式

HRID 2255685 の反応式
[CH:1]12[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH:5]1[CH2:4][CH2:3][N:2]2[C:16]([O:18][CH2:19][CH3:20])=[O:17].[OH-].[Na+]>C(Cl)(Cl)Cl>[CH:1]12[CH2:8][NH:7][CH2:6][CH:5]1[CH2:4][CH2:3][N:2]2[C:16]([O:18][CH2:19][CH3:20])=[O:17]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 191009335-(1,1-Dimethylethyl) 1-ethyl hexahydropyrrolo[3,4-b]pyrrole-1,5-dicarboxylate

生成物 1

HCID 15070028Ethyl 2,7-diazabicyclo[3.3.0]octane-2-carboxylate

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

15.2 g (53.3 mol) of 2-ethyl 7-tert.-butyl 2,7-diazabicyclo[3.3.0]octane-2,7-dicarboxylate in 100 ml of chloroform are heated under reflux for five hours with 10.5 g (55.3 mol) of para-toluenesulphoic acid. The mixture is washeds with 50 ml of 10% strength sodium hydroxide solution, the organic phase is dried over potassium carbonate and concentrated, and the residue is distilled.

後処理

  1. dry with materialthe organic phase is dried over potassium carbonate
  2. concentrationconcentrated
  3. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-1d3c889c1bd3449bb7eadfc4c870dee8
出典データセット
uspto-grants-1993_08
特許番号
US05241076

反応ノート

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