Water → 4-(Trifluoromethyl)indoline

HRID 225572ノート

反応式

HRID 225572 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2.C([BH3-])#N.[Na+].O.[OH-].[Na+]>C(O)(=O)C>[F:13][C:2]([F:1])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH2:6][NH:7]2

参加物

6

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 5003444Sodium cyanoborohydrideHCID 198037034-(Trifluoromethyl)-1H-indole

生成物 1

HCID 162444454-(Trifluoromethyl)indoline収率 76%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

4.4 mmol of 4-trifluoromethyl-1H-indole were dissolved in 8 ml acetic acid. 8.8 mmol of sodium cyanoborohydride were added at once and the reaction mixture stirred at room temperature for 3.5 hours. 20 ml of water were added. The reaction mixture is treated with aqueous sodium hydroxide 40% until basic. Extraction with ethyl acetate yields the crude title compound as a yellowish waxy solid. Yield=76%. MS (m/e): 188.4 ([M+H]+, 97%).

後処理

  1. extractionExtraction with ethyl acetate

出典と根拠

ORDレコード
ord-1bc62934a31c4a219546eb3e7d81dd16
出典データセット
uspto-grants-2009_07
特許番号
US07557114B2

反応ノート

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