1-Benzyloxycarbonyl-4-(2-fluoropyrid-3-yl)piperidine → 2-Fluoro-3-(piperidin-4-YL)pyridine
反応式
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[C:18]([F:23])=[N:19][CH:20]=[CH:21][CH:22]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>FC(F)(F)C(O)=O.C(Cl)(Cl)Cl>[F:23][C:18]1[C:17]([CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)=[CH:22][CH:21]=[CH:20][N:19]=1参加物
4
実験手順
A solution of 1-benzyloxycarbonyl-4-(2-fluoropyrid-3-yl)piperidine (0.36 g) in 5 mL of trifluoroacetic acid was heated to reflux for 30 minutes and evaporated. The residue thus obtained was dissolved in chloroform and evaporated. After repeating this process three times, the named product was obtained as an oil (0.64 g); MS: 181; NMR: 1.6-2.1 (m, 4), 3.0-3.4 (m, 5), 7.2-7.5 (m, 2), 7.8-7.9 (m, 4), 8.1 (m, 1), 8.2-8.8 (br, 2).
後処理
- temperatureto reflux for 30 minutes
- customevaporated
- customThe residue thus obtained
- customevaporated
出典と根拠
- ORDレコード
- ord-a3865e1e22e34791982fe1e286dcdf22
- 出典データセット
- uspto-grants-1997_08
- 特許番号
- US05654299
反応ノート
読み込み中…