Nitric Acid → HCID 57753207、化合物
反応式
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[NH:10][C:9]2=[O:16]>OS(O)(=O)=O.O=S(=O)=O>[F:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][C:14]=1[N+:1]([O-:4])=[O:2])[C:11](=[O:15])[NH:10][C:9]2=[O:16]参加物
4
実験手順
To 753 mmol fuming nitric acid at 0° C. was added dropwise 150 ml 20% oleum. 150.6 mmol 5-fluoro-isoindole-1,3-dione was then added portionwise and the resulting suspension was allowed to warm to room temperature over 4 hours and then stirred for a further 16 h at room temperature and finally was heated at 50° C. for 3 h. The reaction mixture was poured onto ice and the resulting mixture was filtered and the filter cake dried in vacuo to afford the title compound as a yellow solid (68% yield). MS (m/e): 209.1 ([M−H]−, 100%).
後処理
- temperaturefinally was heated at 50° C. for 3 h
- additionThe reaction mixture was poured onto ice
- filtrationthe resulting mixture was filtered
- customthe filter cake dried in vacuo
出典と根拠
- ORDレコード
- ord-ed728841202543b4a9281bf872b1a6ee
- 出典データセット
- uspto-grants-2009_07
- 特許番号
- US07557114B2
反応ノート
読み込み中…