Trifluoroacetic acid → (Piperidin-4-yloxy)acetic acid methyl ester hydrochloride

HRID 2257913ノート

反応式

HRID 2257913 の反応式
F[C:2](F)(F)C([O-])=O.[NH:8]1[CH2:13][CH2:12][CH:11]([O:14][CH2:15][C:16]([OH:18])=[O:17])[CH2:10][CH2:9]1.FC(F)(F)C(O)=O.S(Cl)([Cl:28])=O>ClCCl.CO>[ClH:28].[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][CH2:15][C:16]([O:18][CH3:2])=[O:17])[CH2:12][CH2:13]1

参加物

7

反応物 4

HCID 6422Trifluoroacetic acidHCID 24386Thionyl ChlorideHCID 84468TrifluoroacetateHCID 184236272-(Piperidin-4-yloxy)acetic acid

生成物 1

HCID 21835549(Piperidin-4-yloxy)acetic acid methyl ester hydrochloride

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

By esterifying the trifluoroacetate of 4-piperidinyloxy-acetic acid (prepared by treating the product of Example 1c) with trifluoroacetic acid in dichloromethane) in methanol in the presence of thionyl chloride there is obtained methyl 4-piperidinyloxyacetate hydrochloride, MS (EI): 173 (M)+.

後処理

  1. customprepared

出典と根拠

ORDレコード
ord-bbff8b45f5ae4d93b3165d8c0b688897
出典データセット
uspto-grants-1997_08
特許番号
US05658928

反応ノート

読み込み中…