Benzoyl Peroxide → 2-(Bromomethyl)-7-chloroquinoline

HRID 22584

反応式

HRID 22584 の反応式
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[CH:19]=[C:18]2[C:13]([CH:14]=[CH:15][C:16]([CH3:20])=[N:17]2)=[CH:12][CH:11]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:1][CH2:20][C:16]1[CH:15]=[CH:14][C:13]2[C:18](=[CH:19][C:10]([Cl:9])=[CH:11][CH:12]=2)[N:17]=1

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 1383957-Chloro-2-methylquinoline

生成物 1

HCID 102441602-(Bromomethyl)-7-chloroquinoline

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A stirred suspension of N-bromosuccinimide (9.0 g), 7-chloroquinaldine (9.0 g), dibenzoylperoxide (0.5 g ) in CCl4 (200 ml) at 90° was illuminated with a 225W sunlamp for 6 hours. The suspension was cooled and passed through a plug of silica gel. The plug of silica gel was washed with 30% ether in hexane and the filtrate was evaporated. Flash chromatography of the residue using 30% ether in hexane afforded the title compound.

後処理

  1. temperatureThe suspension was cooled
  2. washThe plug of silica gel was washed with 30% ether in hexane
  3. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-fbd00b5413db49c0a6a962721018cef8
出典データセット
uspto-grants-1995_06
特許番号
US05428171

関連ノート

読み込み中…