L-Tryptophan → Tryptophanol
反応式
[NH2:1][C@H:2]([C:13](O)=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH2:1][CH:2]([CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1)[CH2:13][OH:14]参加物
4
実験手順
L Tryptophan (10.2 g) was cautiously added in portions to a stirred solution of lithium aluminium hydride in tetrahydrofuran (1M, 150 ml). The reaction was stirred for 72 hours and then heated to reflux for 1 hour. The reaction mixture was cooled and then quenched carefully with 2N sodium hydroxide (150 ml). Ethyl acetate (500 ml) was added and the mixture was filtered through a pad of Celite. The organic phase was washed with water, dried (MgSO4) and evaporated to yield the crude title compound.
後処理
- temperatureheated
- temperatureto reflux for 1 hour
- temperatureThe reaction mixture was cooled
- customquenched carefully with 2N sodium hydroxide (150 ml)
- additionEthyl acetate (500 ml) was added
- filtrationthe mixture was filtered through a pad of Celite
- washThe organic phase was washed with water
- dry with materialdried (MgSO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-b0ad0d2884434937b8319f2bbf59ed84
- 出典データセット
- uspto-grants-1995_12
- 特許番号
- US05472978
反応ノート
読み込み中…