Water → HCID 14514900、化合物

HRID 2259730ノート

反応式

HRID 2259730 の反応式
[CH2:1]1[O:12][C:11]2[CH:10]=[C:9]3[C:5]([CH2:6][CH2:7][C:8]3=[O:13])=[CH:4][C:3]=2[O:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[CH2:1]1[O:12][C:11]2[CH:10]=[C:9]3[C:5]([CH2:6][CH2:7][CH:8]3[OH:13])=[CH:4][C:3]=2[O:2]1

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 2483515,6-Methylenedioxy-1-indanoneHCID 21226445Aluminium lithium hydride

生成物 1

HCID 14514900HCID 14514900、化合物収率 80.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 30 g of 5,6-methylenedioxyindan-1-one in 120 ml of tetrahydrofuran was added dropwise to a suspension of 2.4 g of lithium aluminum hydride in 160 ml of anhydrous tetrahydrofuran under cooling with ice. The mixture was stirred at room temperature overnight. 2.4 ml of water, then 2.4 ml of 15% aqueous sodium hydroxide solution and finally 7.2 ml of water were added thereto and insoluble substances were filtered off. The filtrate was distilled and the residue was washed with diisopropyl ether to obtain 24.3 g of the intended compound in the form of faint brown crystals.

後処理

  1. temperatureunder cooling with ice
  2. filtrationinsoluble substances were filtered off
  3. distillationThe filtrate was distilled
  4. washthe residue was washed with diisopropyl ether

出典と根拠

ORDレコード
ord-0d4c7fb707034d52bf4f229252a38afe
出典データセット
uspto-grants-1995_12
特許番号
US05475024

反応ノート

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