Chloroacetyl chloride → N'-(2-chloroacetyl)-2,2-dimethylpropanehydrazide

HRID 2261308

反応式

HRID 2261308 の反応式
[CH3:1][C:2]([CH3:8])([CH3:7])[C:3]([NH:5][NH2:6])=[O:4].[Cl:9][CH2:10][C:11](Cl)=[O:12].C(=O)([O-])O.[Na+]>O1CCCC1>[Cl:9][CH2:10][C:11]([NH:6][NH:5][C:3](=[O:4])[C:2]([CH3:8])([CH3:7])[CH3:1])=[O:12]

参加物

5

反応物 3

HCID 6577Chloroacetyl chlorideHCID 516892Sodium BicarbonateHCID 5451472,2-Dimethylpropanehydrazide

生成物 1

HCID 54595759N'-(2-chloroacetyl)-2,2-dimethylpropanehydrazide収率 54.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Under a nitrogen atmosphere, 2.86 g of 2,2-dimethylpropanohydrazide was dissolved in tetrahydrofuran, and 2.78 g of chloroacetyl chloride was then added at 0° C. The mixture was stirred at room temperature for 18 hours. After aqueous saturated sodium hydrogen carbonate was added, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride, dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain 2.58 g of N′-(chloroacetyl)-2,2-dimethylpropanohydrazide.

後処理

  1. extractionthe reaction mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with aqueous saturated sodium chloride
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-f5cf7205564d4fd7923659e905550472
出典データセット
uspto-grants-2010_12
特許番号
US07846956B2

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