Iodoethane → HCID 1475693、化合物

HRID 2261364ノート

反応式

HRID 2261364 の反応式
[CH3:1][N:2]1[C:6]([CH2:7][OH:8])=[CH:5][N:4]=[C:3]1[SH:9].[CH3:10][C:11](C)([O-])C.[K+].C(I)C>O1CCCC1>[CH2:10]([S:9][C:3]1[N:2]([CH3:1])[C:6]([CH2:7][OH:8])=[CH:5][N:4]=1)[CH3:11]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 23665647Potassium tert-butoxideHCID 178481144HCID 178481144、化合物

生成物 1

HCID 1475693HCID 1475693、化合物収率 93.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

4.33 g of (1-methyl-2-mercaptoimidazol-5-yl)methanol was added to 90 ml of tetrahydrofuran. Thereto 3.70 g of potassium t-butoxide and 5.15 g of ethyl iodide were then added under ice-cooling. The mixture was stirred at room temperature for 1 hour. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 4.82 g of (2-ethylthio-1-methylimidazol-5-yl)methanol.

後処理

  1. temperaturecooling
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-22d3fcb699e14d9199e3e02548618ede
出典データセット
uspto-grants-2010_12
特許番号
US07846956B2

反応ノート

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