Ethyl bromoacetate → (2-Acetyl-4-methoxy-phenoxy)-acetic acid ethyl ester

HRID 226263

反応式

HRID 226263 の反応式
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[OH:12])=[O:3].C(=O)([O-])[O-].[K+].[K+].Br[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>CCC(C)=O>[CH2:24]([O:23][C:21](=[O:22])[CH2:20][O:12][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH3:11])=[CH:9][C:4]=1[C:2](=[O:3])[CH3:1])[CH3:25]

参加物

5

反応物 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 697141-(2-Hydroxy-5-methoxyphenyl)ethan-1-one

生成物 1

HCID 15643798(2-Acetyl-4-methoxy-phenoxy)-acetic acid ethyl ester

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A mixture of 16.6 g (100.0 mmol) of 2-hydroxi-5-methoxyacetophenone, 20 g (208 mmol) of potassium carbonate, 16.7 g (100.0 mmol) of ethyl bromoacetate and 200 ml of MEK is stirred at reflux temperature for 10 hr. The solids are filtered and the filtrate concentrated. The residue is suspended in water and the solid is filtered and dried. Yield: 10.2 g (40%).

後処理

  1. temperatureat reflux temperature for 10 hr
  2. filtrationThe solids are filtered
  3. concentrationthe filtrate concentrated
  4. filtrationthe solid is filtered
  5. customdried

出典と根拠

ORDレコード
ord-60bd36e5ee7d4e22abc36d0cbb75c24c
出典データセット
uspto-grants-2009_07
特許番号
US07557212B2

関連ノート

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